Presentation Each capsule contains Doxycycline Hydrochloride BP equivalent to Doxycycline 100 mg.

Description Doxycycline is a semisynthetic derivative of oxytetracycline. Doxycycline is a broad spectrum antibiotic with the broadest spectrum of any known antibacterial agent. It is active against a wide range of gram-positive and gram-negative bacteria, spirochetes, mycoplasma, rickettsiea etc. It can be used with success in place of penicillin in the treatment of gonorrhoea and syphilis.

Pharmacokinetics Doxycycline has an excellent mode of absorption and is almost completely absorbed (95%) from the GIT. Food does not interfere with the absorption of doxycycline, 90% of the drug in circulation is bound to plasma protein. Biological half-life varies between 16- 23 hours on repeated doses. Due to its higher lipid solubility than any other tetracycline ,doxycycline attains a wide distribution in body tissues and body fluids.

Indications and Uses Doxycycline is indicated for the treatment of infections caused by susceptible microorganisms: RTI infections: pneumonia, influenza, pharyngitis, tonsillitis, bronchitis, sinusitis and otitis media and other Streptococcal and Staphylococcal infections. Genitourinary Tract infections: Pyelonephritis, Cystitis, urethritis, Gonorrhoea epididymitis, Syphilis, Chancroid and Granuloma inguinale. Chlamydia: Lymphogranuloma, venereum, psittacosis, trachoma. Intestinal disease: Whippies disease, tropical sprue, blind loop syndrome, amoebic dysentery. Bacillary infections: Brucellosis, tularaemia, cholera, traveler's diarrhoea. Acne: Acne vulgaris, acne conglobata etc. Other infections: Typhus, actinomycosis, rickettsialpox and Q-fever and infections caused by Mycobacteriam marinum, Bordetella pertussis and Bacillus anthracis

Contraindications Doxycycline is contraindicated in patients who have known hypersensitivity to Doxycycline

Dosage And Administration Adults: 2 Doxycycline capsules at a time or one capsule every 12 hour for the first day followed by 1 capsule per day. The dose may be doubled depending on the severity of the infection. Gonococcal infection: 1 Doxycycline capsule every 12 hours until complete recovery. Syphilis: 3 Doxycycline capsules in divided doses for 10 days.

Precautions During development of teeth (last trimester of pregnency, upto 12 yrs of age) the use of tetracyclines may lead to discoloration of teeth. So tetracyclines should not be administered during these periods

Side Effects As with all other antibiotics, side effects liable to be encountered include: Gastrointestinal disterbances,eg. anorexia, vomiting, dysentry etc. overgrowth of resistant organisms may cause Glossitis, Stomatitis, or Staphylococcal enterocolitis; Apart from these skin rashes, purpura may occur. Photosensitivity and dermatological reactions are rare.

Use in pregnancy & lactation Alkali, antacids or irons should not be taken along with Doxycycline. Because these may reduce the absorption of the drug. This drug should not be administered to pregnant woman. But in emergency cases it may be administered upon the advice of the doctor.